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Molecular patches skip a faulty gene segment

Molecular patches are short molecules that bind to a gene transcript near a faulty segment. The cell’s splicing machinery then leaves that segment out and builds a shortened protein that can still work.

In the picture

  1. A green clamp-like molecular patch bound to a grey spacer block on the strand
  2. A cracked red gene segment between the two patches
  3. A scissor-shaped enzyme at the cut junction beside the red segment
  4. A shortened folded protein chain in the cytoplasm outside the nucleus

Examples

  • A film editor removes one damaged scene so the rest of the movie still plays.
  • A train route skips a closed station and continues to its destination.

Quiz: Molecular patches skip a faulty gene segment (Age 18)

  1. What do molecular patches do to the faulty gene segment?

    • They repair the mutation directly in the DNA.
    • They mark it so the splicing machinery skips it.
    • They replace the whole gene with a new copy.
  2. After the faulty segment is skipped, what does the cell build?

    • A full-length protein with the faulty segment repaired.
    • A shortened protein that can still work.
    • No protein at all.
  3. Why can exon-skipping therapy reduce the effects of the mutation?

    • Because the molecular patch becomes part of the final protein.
    • Because the faulty segment is removed from the DNA itself.
    • Because the shortened protein can keep enough function.

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Biology, Age 18