Molecular patches skip a faulty gene segment
Age 18 · Biology
Molecular patches are short molecules that bind to a gene transcript near a faulty segment. The cell’s splicing machinery then leaves that segment out and builds a shortened protein that can still work.
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In the picture
- A green clamp-like molecular patch bound to a grey spacer block on the strand
- A cracked red gene segment between the two patches
- A scissor-shaped enzyme at the cut junction beside the red segment
- A shortened folded protein chain in the cytoplasm outside the nucleus
Examples
- A film editor removes one damaged scene so the rest of the movie still plays.
- A train route skips a closed station and continues to its destination.
Key takeaways
- Molecular patches mark the faulty segment so the splicing machinery skips it.
- The shortened protein can keep enough function to reduce the effects of the mutation.
Quiz: Molecular patches skip a faulty gene segment (Age 18)
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What do molecular patches do to the faulty gene segment?
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After the faulty segment is skipped, what does the cell build?
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Why can exon-skipping therapy reduce the effects of the mutation?
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