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Waking a Dormant Photoreceptor

In some forms of blindness, photoreceptor cells stay in the retina but no longer respond to light. Gene therapy delivers a gene for a light-sensitive protein into those cells so they can signal light again.

In the picture

  1. Delivery capsule: a shell carrying genetic material
  2. DNA strand: the gene for a light-sensitive protein, threading into the cell
  3. Dormant photoreceptor: a pale cell that no longer responds to light
  4. Woken photoreceptor: a cell filled with the light-sensitive protein, glowing green
  5. Light beam: the light the woken cell can now detect and signal

Examples

  • A phone with a flat battery: nothing is broken, it just needs energy to work again.
  • An intact solar panel that only produces current once the circuit is connected.

Quiz: Waking a Dormant Photoreceptor (Age 18)

  1. What happens to the photoreceptor cells in this condition before gene therapy?

    • They stay in the retina but no longer respond to light.
    • They are missing from the retina because they have died.
    • They remain in the retina and respond to light normally.
  2. What does the gene therapy deliver into the dormant photoreceptor cells?

    • A gene for a protein that protects the cell from light damage
    • A gene for a light-sensitive protein
    • A gene for a protein that makes the cell produce new photoreceptors
  3. What does the light-sensitive protein restore in the woken photoreceptor?

    • Its ability to become a different retinal cell
    • Its ability to send signals
    • Its ability to stay permanently dormant

The answers, each with its explanation, are in the app. This lesson has left the free week, so its quiz is part of the subscription.

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Biology, Age 18